Anglais Structural Biology in Drug Discovery

About

With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field.
The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins


  • Authors

    Jean-Paul Renaud

  • Publisher

    Wiley

  • Distributeur

    Numilog

  • Publication date

    09/01/2020

  • EAN

    9781118900505

  • Availablity

    Available

  • Copy

    No

  • Print

    Authorized with restriction

  • Print count

    688

  • Poids

    43 837 Ko

  • Diffuseur

    Numilog

  • Entrepôt

    Numilog

  • Support principal

    ebook (ePub)

  • Version ePub

Aucune information sur l'accessibilité n'est disponible

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